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Dettagli: Institute of Protein Biochemistry, CNR.
Via P. Castellino, 111 - 80131 Napoli
2015 IBP Seminar Series
CNR Conference Room
Wednesday, November 4th, 2015 at 14:30
Prof. Cesare Montecucco
Department of Biomedical Sciences, University of Padova, Italy
"Mitochondrial Alarmins are key intercellular signals in neurodegeneration/regeneration of the neuromuscular junction"
Host: Dr Daniela Corda
Tel. 081-6132536; e-mail: d.corda@ibp.cnr.it
The neuromuscular junction is one of the few human tissues capable of complete regeneration after major damages. Prof Montecucco’s group has set up a reliable model of acute degeneration of the motor axon terminals followed by complete recovery of function. They have found that alarmins released by mitochondria of the degenerating nerve terminal are key factor that act on the perisynaptic cells and muscle fibre. These cells are activated and release signals that act retrogradely on the nerve terminal inducing its regeneration.
www.biomed.unipd.it/research/neurotoxins-neuroparalysis-and-regeneration/overview/
Dr Maria Rosaria Coscia & Stefania Mariggiò
Seminar Coordinators
Institute of Protein Biochemistry, CNR
Via P. Castellino, 111
80131 Naples Italy
Tel 0039 081 6132556/545 |