Contributions@DSB | List Abstracts

The Institutes of the DSB - November 2020

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360 records found
Inst.	Title	Keywords	Contacts
IRIB	"SeNSO" SEnsore Nanostrutturato per Stress Ossidativo	oxidative stress, electrochemical sensor, hydrogen peroxide	E. Pace
IBBC	"Shedding laser light" on the molecular and cellular functions of DDX11 and FANCJ DNA helicases	DNA replication; Genome stability; Cell cycle; DNA helicases; Fork-protection complex	F. M. Pisani
IBBC	“Antarctized” antibody: an innovative monoclonal antibody engineered by the CRISPR/Cas9 system	engineered monoclonal antibody; genome editing; Immunoglobulin gene locus	M.R. Coscia
IGM	3D Muscle-Tendon Unit modelling for unravelling tissue crosstalk in muscular dystrophies and aging	---	G. Lattanzi, E. Mattioli et al.
ITB	A bioinformatic landscape for ncRNA data analysis and functional characterization	ncRNA, bioinformatics, gene regulation	F. Licciulli
IGB	A crossroad of epigenetic/omic control: insights into the KAP1/ZFP57 network of factors	Epigenome; DNA methylation; KAP1/ZFP57	G. Grimaldi
IBPM	A green technology to remove arsenic from soils and drinking water	arsenic; phytoremediation; environment	P. Brunetti, M. Cardarelli
IBBC	A monoclonal antibody targeting connexin hemichannels as novel therapeutic approach for the treatment of Clouston syndrome	Antibody drug discovery, Connexins, Genodermatosis, Epidermis, Sebocytes, Calcium, ATP	C. Peres, F. Mammano
IBB	A new platform for generating multispecific antibody formats and new antibody drug conjugates	Multimeric antibody formats, Recombinant Fab, Trastuzumab, Cripto-1, ADC	M. Ruvo
IBB	A stapled AIF mimicking peptide targeting AIF/CypA lethal complex	neurodegenerative and heart diseases, protein-protein interaction, drug development	N. Doti
IBFM	Abnormal metabolic states, aging, gender and neurodegenerative processes	Aging, Metabolism, Neuroinflammation	S. Belloli
IGM	Abstract	DNA repair, RNase H2, DNA Pol Lambda	E. Crespan
IN	AChE inhibitors as regulators of α7nAChR and its human-restricted duplicated isoform, CHRFAM7A, expression and modulation of the cholinergic antiinflammatory pathway in AD	CHRNA7, CHRFAM7A, cholinergic anti-inflammatory pathway	R. Benfante
IN	ACTION OBSERVATION TREATMENT FOR MOTOR REHABILITATION	Action observation, plasticity, motor abilities, neurorehabilitation, motor imagery	P. Avanzini
IN	ACTION PREDICTION	action prediction, motor intention, action planning, action preparation, driving	G. Vecchiato
IBB	Advanced approach for ApoE−/−Fbn1C1039G+/−mouse characterization: a suitable model of vulnerable atherosclerotic plaque	Atherosclerosis, High Frequency Ultrasound, mouse model	S. Albanese
IBBC	Advanced label-free microscopy for application in cell biology	Raman microscopy, SERS, imaging, label-free, cancer	A.C. De Luca
IBBC	Advanced morphology: imaging and microscopy	Euro-bioimaging infrastructure, Advanced morphology: imaging and microscopy, mammalian secretory pathway	M. Pirozzi
IFT	Aging and senescence: from DNA damage to muscle regeneration	---	L. Latella
IN	Altered forebrain GABAergic postanatal inhibitory interneurons in a mouse model of intellectual disability- autism spectrum disorder	ID-ASD, inhibitory interneurons, postnatal neurogenesis, OPHN1	C. Lodovichi
IN	Altered protein translation pathways in epilepsy	Protein translation, Dravet syndrome, inhibitory synapses, genetic models of epilepsy	C. Sala
IGM	Alternative splicing regulation in angiogenesis and in tumor vasculature	Alternative splicing, Angiogenesis, RNA Binding Proteins	C. Ghigna
IGB	Alu RNAs as novel therapeutic targets and biomarkers in colorectal cancer	Alu RNAs, colorectal cancer, exosomes	V. Tarallo
IN	An Angiopep2-PAPTP construct overcomes the blood-brain-barrier. Perspectives against glioblastoma	PAPTP, Angiopep-2, Brain delivery	L. Biasutto
IBBC	An integrated platform for specific and selective histone deacetylase inibitors (HDACiPLAT)	Istone deacetylase inhibitors, Schistosoma mansoni, cancer, integrated drugdiscovery platform	G. Ruberti, F. Saccoccia
IBIOM	Analysis of microbial communities in agro-food, environmental, animal and human samples by metagenomic approaches	Metagenomics, Microbiome, Extremophiles	L. Ceci
IFT	Analysis of the genetic and functional mechanisms underlying the inflammatory immunological response processes in the field of kidney transplants and in oncology: definition of biomarkers predicting immune dysregulation	HLA, kidney transplantation, cancer, stem cell transplantation, KIR, CTLA-4	A. Canossi
IBBC	Antioxidant action of plant polyphenols in the counteraction of alcohol-abuse induced damage: Impact on the Mediterranean diet	AUD, NGF, BDNF, oxidative stress	M. Fiore
IFT	A-to-I RNA editing in cancer	RNA editing, post-transcriptional modifications, glioblastoma therapy	V. Cesarini
IBPM	Automated high-content imaging to study the response of human cells to novel anti-cancer treatments and identify new therapeutic targets	single-cell imaging; high-content microscopy; genotype/phenotype analysis	L. Asteriti, C. Rinaldo
IBBC	Autoregulatory circuit regulating basolateral cargo export from the TGN: role of the orphan receptor GPRC5A in PKD signaling and cell polarity	Apico-basal polarity, autoregulatory systems, basolateral cargo, PKD signaling, TGN export	R. Di Martino
IBPM	Bacterial P450 cytochromes as tools for designing alternative pharmacological agents	cytochromes P450; structural Biology; drug design and discovery	L. C. Montemiglio, C. Savino
IBB	BactiVax, a European Anti-Bacterial Innovative Vaccine Training Network	Bacterial infections, respiratory disease, protein structure	R. Berisio
IRIB	Big data in Environmental and occupational EPidemiology (BEEP)	Air pollution; Big Data; Hospitalization; Morbidity; Mortality; Noise; Temperature	S. La Grutta, G. Viegi
IBBC	Biochemical and molecular studies on enzymes involved in cell detoxification	regulation of catalysis; structure-function relationships; detoxification	G. Manco
IBPM	Biocrystal Facility: a structural biology hub for Italian researchers and companies	structural biology; X-ray crystallography; single particle cryo-electron microscopy	L. C. Montemiglio, A. Di Matteo
ITB	Bioinformatics @ ITB	bioinformatics, computational biology, BigData integration	F. Licciulli, E. Mosca
IGM	Bioinformatics data analysis @IGM	Bioinformatics, Data analysis, Cloud computing	R. Alfieri
IBPM	Bioinformatics@IBPM: from atomic level to genome-scale data analysis, and the ELIXIR-Italy Training Platform	structural bioinformatics; computational genomics; ELIXIR training	T. Colombo, L. Le Pera
ITB	Biomedical image and signal processing	medical imaging, biomedical signal processing, image-based biomarkers	G. Rizzo
IN	Biomolecular condensates in neuromuscular and neurodegenerative diseases	TDP43, secretory phospholipases A2, phase transition	F. Tonello, M. L. Massimino
IBB	Biomolecular NMR spectroscopy	NMR spectroscopy, biomolecular interactions; drug discovery	D. Diana, M. Leone
IGM	Bone Cancer Group, IGM-CNR, UOS Bologna	Sarcoma, RNA metabolism, stress/inflammation	W. Blalock, M.Piazzi
IN	Boosting cholinergic signaling to rescue social deficits in an animal model of Autism	social memory, CA2 region,, interneurons	M. Griguoli
IN	Cadherin dysfunctions hack brain wiring leading to neurodevelopmental disorders	encephalopathy, epilepsy, autism	M. Passafaro
IBPM	Calcium dyshomeostasis as a marker of ER stress, chemotherapeutic drug resistance and neurodegeneration	calcium homeostasis; cancer; neurodegeneration	G. Colotti, A. Ilari
IGB	Cancer Molecular Analysis by ‘OMIC’ and ‘Cancer Modeling’	Patient-derived Tumor Organoids; Drug Resistance; Anti-cancer agents	E. Caputo
IGB	Cancer-specific ultraconserved long noncoding RNA 8 as a novel biomarker for early bladder cancer detection	Bladder cancer; prognostic biomarker; ultraconserved region; Transcribed-ultraconserved region; long noncoding RNA; ultraconserved transcript 8+: uc.8+;	A. Cimmino
IBBC	Cardiac stromal cells biology and contribution to tissue repair and regeneration	Cardiac repair, stromal cells, regeneration	F. Pagano
IGB	Cardiogenesis and congenital heart disease	Congenital heart disease, Multipotent Cardiac Progenitor , Extracellular matrix	D. Alfano, G. Lania
IN	Cellular and Molecular Mechanisms in neurodevelopmental disorders and brain tumors	FOXG1-related disorders; glioblastoma; cell signalling	M. Costa
IN	Cellular and molecular mechanisms of neuronal disease	mitochondrial bioenergetics, intracellular calcium balance, neuronal metabolomics	L. Colombaioni
IBFM	Characterization of cancer evolution and intra-tumor heterogeneity from single-cell sequencing data	Cancer evolution, Intra-tumor heterogeneity, Omics data integration, artificial intelligence, machine learning, single-cell sequencing, scRNA-seq data	A. Graudenzi
IBBC	Characterization of novel lncRNA associated to EMT intermediate phenotypes and resistance to target therapy in NSCLC (LEARN)	long non coding RNA (lncRNA), non small cell lung cancer (NSCLC), target-therapy resistance, epithelial to mesenchimal transition (EMT)	G. Ruberti, V. Fustaino
IRGB	Characterization of the immune response in murine models of disease	immunodeficiency, autoimmunity, innate and adaptive immunity, murine models	V. Marrella
IN	Characterization of the intracellular and mitochondrial Ca2+ signaling in physiology and pathology	mitochondrial Ca2+; Ca2+ signaling; human pathology	G. Pallafacchina
IRGB	Chromosome Transplantation, a new approach to treat X-linked diseases	Genetic Therapy; Chromosome Transplantation; X-linked Diseases; Lesch Nyhan Disease, X-linked Duchenne Muscular Dystrophy	M. Paulis
IRGB	Cigarette Smoke: Study of Immune system dysregulation in the ProgeNia cohort	Cigarette smoke, Immune system, Transcriptome profiling	M. Marongiu, V. Serra, V. Orrù, M. Pala, M. Steri
IBB	Circulating extracellular vesicles with liver-specific RNA species and proteome are potential biomarkers for early liver fibrosis in experimental cholestasis	fibrosis, extracellular vesicles, biomarkers	S. Fagoonee
ITB	Circulating miRNAs in small extracellular vesicles secreted by a human melanoma xenograft in mice brain	extracellular vesicles; microRNAs; metastatic melanoma	I. D'Agnano
IFT	Classical and non-classical HLA polymorphisms in long-term monitoring of kidney transplantation and diseases	HLA-G, transplantation, obesity	D. Piancatelli
IRGB	Clinical translational research using NGS technologies: DNA methylation, gene mutations and circulating microRNAs, from bench to clinic	NGS, Diagnostic biomarkers, Liquid biopsy, microRNA, DNA methylation, Gene mutation	R. Roncarati
IBBC	CNR-IBBC Monterotondo mutant strain production: open doors for new mouse models	genetically modified mouse models	F. Chiani, A. Gambadoro, M. Pasquini
IRGB	Cohesin: a new player in cancer development	Cohesin, Cancer, Rare diseases	A. Musio
IBFM	Computational methods for biomedical data science	biomedical data science, data integration, multi omics, AI, machine learning, cancer evolution, SARS-CoV-2, metabolic networks, precision medicine	A. Graudenzi
IBBC	Connexin hemichannel-mediated ATP release drives spontaneous Ca2+ signaling in the greater epithelial ridge of the developing cochlea	whole cell-based biosensors, ATP release, connexin hemichannels, calcium signaling, developing cochlea, microfluidic chip	C. Nardin, F. Mammano
IN	CONSCIOUSNESS	timing; neural correlate; tactile awareness; neglect; stroke	P. Avanzini
IBBC	Conserved motifs in the cytoplasmic tails of human Golgi-glycosyltransferases regulate enzyme dynamics	Golgi, glycosyolation, cancer, trafficking, GOLPH3	D. Russo, A. Luini
IBBC	Covid-19 and science communication: an opportunity to assess new formats in public engagement	Covid19, science communication, digital transformation, public engagement	G. Catara
IN	Creatine Deficiency Syndrome: novel insight into brain function and therapeutic strategies	creatine, intellectual disability, gene therapy	L. Baroncelli
IBBC	D2M – Digital Mouse Monitoring	Artificial Intelligence, Mouse monitoring, Sensors, Home cage monitoring	M. Raspa
IGM	DAXX HISTONE CHAPERONE MODULATES DOUBLE STRAND BREAKS REPAIR PATHWAY CHOICE THROUGH H3.3 DEPOSITION	DNA repair, Double strand breaks, Histone variant	G. Buscemi
ITB	Deciphering the role of DNA compartmentalization in human diseases	Chromatin conformation, laminopathies, cancer	C. Lanzuolo
IN	Defining the mechanisms underpinning the mitochondrial cAMP signalling	cAMP, mitochondria, signalling microdomains	G. Di Benedetto
IFT	Degenerative and genetic brain diseases: correcting synaptic and circuits dysfunctions to rescue cognition	pre-sympthomatic Alzheimer Disease; memory; neural compensation; synaptic plasticity; network disfunciton; Autism Spectrum Disorder; Gender specificity; Chemogenetic Tools.	A. Pignataro
IBBC	Detection of sleep-related disturbances in mouse models of neurological diseases using a novel automated home cage monitoring system	ALS, sleep, circadian rhythm, home cage monitoring4, neurodegeneration, neuromuscular diseases, mouse behavioral phenotyping	S. Mandillo
IN	DEVELOPING A BRAIN CLEARING TECHNIQUE TO STUDY FUNCTIONAL CONNECTIVITY	brain clearing; functional connectivity; high-throughput analysis; quantitative image analysis	S. Morara
IFT	Development of innovative biotechnological and therapeutic strategies in Regenerative Medicine and Tissue Engineering	Rigenerative Medicine, Tissue engineering, Nano-biotecnology	A. Lisi, M. Ledda
IBB	Development of integrin subtypes selective peptides for theranostic applications	Integrins, selective peptide ligands, design, synthesis, chemical modification, theranostic, structure-activity relationship	L. Zaccaro, A. Del Gatto
IBFM	Development of multimodal phantom for molecular imaging	Phantoms, Radiomics, 3D printing	F. Gallivanone
IBBC	Development of new bioreceptors to be used in biosensors and/or diagnostic kits for the monitoring of toxic substances in humans and in the environment	Bioreceptors, Biosensors, Toxic molecules, CG-MALS, Fluorescence	F. Febbraio
IBFM	Development of new radioligands for PET/SPET imaging	Radiopharmacology, PET/SPET imaging, Animal models	S. Todde, S. Belloli
IFT	DIAGNOSTIC SERVICES FOR THE BAMBINO GESU’ CHILDREN’S RESEARCH HOSPITAL IRCCS	organ transplantation, HLA polymorphism, alloantibody	G. Ozzella
IBPM	Dissecting the interplay between integrin and endothelin signaling in invadopodia and metastatic process of ovarian cancer: new therapeutic approaches	organoids; cancer cell invasion and metastasis; invadopodia	L. Rosanò
IBPM	Dissecting the role of GOLPH3 in cytokinesis	cytokinesis; GOLPH3; myosin	S. Sechi, M. G. Giansanti
IBPM	Dissecting the role of lncRNAs in skeletal muscle differentiation and regeneration	noncoding RNAs; muscle stem cells; muscle differentiation	J. Martone, C. Mozzetta
IRGB	Dissection of white blood cells regulatory genetic mechanisms using a co-expression network from RNA-seq transcriptomes of 624 individuals	Gene co-expression network, WGCNA, white blood cells	P. Forabosco
IBPM	Drosophila models to study neurodegenerative and neurological disorders	Drosophila; neurodegeneration; neurological disease	M. Di Salvio, G. Cestra
IFT	Dysfunction of RNA/RNA binding proteins in motor neuron diseases	Amyotrophic Lateral Sclerosis, RNA metabolism, neurodegeneration	M. Cozzolino
IN	Early dysfunctions of intracellular Ca2+ signaling and bioenergetics in Alzheimer’s Disease	calcium signaling, FAD (familial Alzheimer’s disease), mitochondria	E. Basso, R. Filadi
IBBC	Effect of cigarette smoke on vascular integrity: the role of circulating miRNAs	miRNA, circulating miRNA, endothelial function	F. Pagano
ESFRI-ELIXIR	ELIXIR-IT: the Italian Node of the European Research Infrastructure for Life Science	Research Infrastructure, Bioinformatics, Integrative Omics	G. Pesole
IRGB	Elucidate the CRLF1 immunoregulatory role through Integrated immunophenotyping, proteomic and transcriptional profiling in CS/CISS1 cases	CRLF1, immune cell function, hematopoiesis, Crisponi/Cold- induced sweating syndrome type 1 (CS/CISS1), CLCF1	L. Crisponi
IFT	Endocannabinoid System in Human Disorders	endocannabinoid system; endocannabinoids, bioactive lipids	T. Bisogno
IN	Entorhinal cortex as a model to study synaptic function and neurodegeneration	Alzheimer’s disease, inflammation, hippocampus	N. Origlia
IN	Epidemiology of aging and biostatistics	epidemiology; aging; healthy aging	F. Limongi, M. Noale
IRGB	Epigenetic and Transcriptional Programs controlling cardiomyocyte proliferation and cardiac fibrosis	Cardiomyocyte proliferation, Fibrosis, Epigenetics	P.L. Cattaneo
IGB	Epigenetic control of cellular identity in human primary immunodeficiencies	Epigenetic syndromes, DNA/Histone methylation, patient-derived iPSCs	M.R. Matarazzo
IBBC	Epigenetics of alcohol consumption and abuse during gestation	Epigenetic, Alcohol Use Disorders, Fetal Alcohol Spectrum Disorders	M. Fiore
IRGB	Erythropoiesis stage specific transcriptional signatures in primary erythroid cells in healthy and β-thalassemia patients	Erythropoiesis; RNAseq; Novel genes	M. Uda, M. Pala
IRGB	ERYTHROPOIESIS, HEMOGLOBIN EXPRESSION AND SWITHCING. THE HUMAN δ-GLOBIN GENE AS A THERAPEUTIC TOOL FOR β- HEMOGLOBINOPATHIES. POST GWAS TARGET VALIDATION AND EVALUATION OF MOLECULES IN PRECLINICAL MODELS.	β-hemoglobinopathies, δ-globin, preclinical mice models	M.S. Ristaldi
ESFRI-EUBI	Euro-BioImaging ERIC – The European Research Infrastructure for Advanced light microscopy (ALM) imaging: general overview and presentation of the Italian ALM Node	Biological imaging, cellular imaging, research infrastructure, ESFRI	S. Parashuraman, E. Greotti
ESFRI-EUBI	Euro-BioImaging ERIC – The European Research Infrastructure for Biological and Medical Imaging: general overview and presentation of the biomedical imaging Italian Nodes	Biomedical imaging, research infrastructure, user access	S. Aime, A. Viale, E. Terreno
IFC	EUROlinkCAT - Long term outcomes in children with congenital anomalies	congenital anomaly, linkage, mortality	A. Pierini
ITB	Exogenous Plant miRNAs have a cross-Kingdom regulatory roles in the human metabolism	exogenous plant miRNAs, ncRNA, cancer	D. Catalano
IBBC	Experimental approaches to investigate the Nerve Growth Factor receptor-mediated actions	biological activity; cleavage; NGF processing; small peptides	P. Tirassa
IGM	EXPLORING THE INVOLVEMENT OF COLVI-NG2 AXIS IN THE GENERATION OF CONTRACTURES AFFECTING UCMD PATIENTS	Collagen type VI-related myopathies, Mechanosignaling, Extra Cellular Matrix	S. Squarzoni, P. Sabatelli
IGM	Exploring the molecular mechanisms regulating vector capacity in the tiger mosquito, Aedes albopictus	arboviruses, RNA helicases, viral replication	F. Scolari
ITB	Exploring transcriptional single-cell signatures in an embryonic mouse model of epilepsy	single-cell RNASeq; embryonic mouse brain; epilepsy	E. Mangano, C. Consolandi
IGB	Extracellular and intracellular control of pluripotency: beyond transcription factors	pluripotency; neural differentiation; non-coding RNAs	A. Fico, G. Minchiotti
IRIB	Extracellular vesicles from a natural source	Extracellular Vesicles (EVs), bio-nanotechnology, drug delivery system, renewable bioresource	A. Bongiovanni
IN	Extracellular Vesicles mediators of anti-inflammatory and neuroprotective action and potential novel biomarkers for Alzheimer’s Disease	Extracellular Vesicles; therapeutical strategy; biomarkers; Alzheimer’s Disease; Mesenchymal Stem Cells	M. L. Malosio
IGB	Extrinsic regulation of muscle stem cells and inflammatory cells in skeletal muscle regeneration and muscular disease	Skeletal muscle regeneration; regenerative medicine; Cripto	G. Minchiotti, O. Guardiola
IFT	From human health findings to the pre-clinical development of new therapeutic strategies	3D-Bioprinting, Neuroinflammation, Parkinson, cannabinoids, opioids, antipsychotics	M.A. Casu
IGB	Functional analysis of hemoglobinophaty mutants and regulation of expression of human lactonase PON2	Hemoglobinotaphies; transciptional analysis; regulation of expression of the PON2 gene	G. Lacerra
IN	Functional effects and molecular mechanisms of the transcytosis of pathogenic molecules	neurotoxins, axonal trafficking, synaptic vesicles	L. Restani
IRGB	Functional impairment of osteoblasts derived from Shwachman-Diamond syndrome patients: new pharmacological approaches to overcome the genetic mutation	Shwachman-Diamond Syndrome, osteoblast, PTC read-through	A. Frattini
IBBC	G protein-coupled receptors’ signaling, cerebellum development and medulloblastoma occurrence	Cerebellum; Proliferation; GPCRs	D. Marazziti, G. La Sala, C. Di Pietro
IBB	Galectins: Structure, function and therapeutic potential inhibitors	galectin-fold; galectin-inhibitor; anti-tumoral agents; Spike protein	E. Pedone
IN	Gene therapy and CRISPR/Cas9 epigenomic editing for treating neurodevelopmental disorders	gene therapy, AAV, CRISPR/Cas9, genome editing, neurodevelopmental disorders	V. Broccoli
IGB	Genetic and epigenetic mechanisms deregulated in Rett syndrome	Rett syndrome; MeCP2; Glycosphingolipids	F. Della Ragione
IRGB	Genetic and molecular alterations in pancreatic cancer by next-generation sequencing	Pancreatic cancer, NGS, targeted therapy	L. Frogheri, M.G. Doro, M.C. Sini
IGB	Genetic and Pharmacological rescue strategies in a neurovascular congenital disease	Brain neurovascular development, genetic and pharmacological rescue, mouse models	S. Cioffi, G. Flore
IBFM	Genetic Biomarkers in Epilepsy	Epilepsy, Imaging biomarkers	A. Gambardella
IFT	Genetic factors predictive of risk of cancer and neurological disease	HLA, CD16, CD1	A. Aureli
IRGB	Genetic regulation of immune traits, implication on diseases and their therapies	Immune traits, GWAS, autoimmunity	V. Orrù, M. Steri, C. Sidore, E. Fiorillo, F. Cucca
IGB	Genetics of common trait and rare diseases in population isolates: the Cilento study	genetic epidemiology, omics data, rare disease	M. Ciullo, D. Ruggiero, T. Nutile
IN	GENETICS OF FAMILIAL TEMPORAL LOBE EPILEPSIES	ADLTE, FMTLE, whole exome sequencing, causal genes, mechanisms of mutations	C. Nobile, E. Dazzo
IGM	Genome integrity and cell cycle checkpoints	DNA damage response; DNA repair; p21-PCNA interaction	E. Prosperi
IGM	Genome-wide characterization of the genomic and splicing features of long non-coding RNAs using bioinformatics approaches	Long non-coding RNAs, Bioinformatics, Splicing mechanisms	S. Bione
IRGB	Germline and somatic NGS-based analysis on BRCA-related tumors	BRCA1-2 genes, NGS, PARP-AR inhibitors	M.C. Sini, G. Palomba, M. Pisano
IN	GLIAL MICROVESICLES IN MOTION AT THE NEURON SURFACE: IMPLICATION IN ALZHEIMER’S DISEASE	extracellular vesicles, synaptic dysfunction, PrP, extracellular motion, Alzheimer’s disease	C. Verderio
IBBC	Golgi complex disassembly duringG2/M transition: An organelle-based cell-cycle checkpoint	Golgi complex, cell cycle, combinatorial treatment, cancer	A. Colanzi
IBBC	Golgi enzyme organization controls fidelity in glycan biosynthesis	Glycosylation, Golgi, cell growth, glycosphingolipids	S. Parashuraman
IRGB	GUT MICROBIOTA FUNCTIONAL DYSBIOSIS AND IMPACT OF INDIVIDUAL DIET IN SUBCLINICAL CAROTID ATHEROSCLEROSIS	Atherosclerotic Cardiovascular Diseases; Gut Microbiota; next generation sequencing	M. Severgnini, C. Peano
IBPM	HD-Zip II transcription factors in auxin-regulated plant development	Arabidopsis; transcription factors; plant development	G. Sessa, M. Carabelli
IFT	Highly specialized services in the field of histocompatibility and assessment of donor / recipient alloreactivity in organ transplantation	organ transplantation, HLA antibodies, AT1R antibodies, C1q antibodies	E. Poggi
IGB	HLA-DQ2.5 genes: role in immuno-modulation mechanisms of Celiac Disease	autoimmunity, HLA, expression	G. Del Pozzo, L. Pisapia
IBB	Host-pathogen interactions in viral diseases: the case of SARS-CoV-2	protein-protein interactions, respiratory disease; protein structure	R. Berisio
ITB	Human brain neuromelanin: from biochemistry to its potential application as biomarker of neurodegeneration	neuromelanin, aging, neurodegeneration	F. A. Zucca
IN	HUMAN EMOTIONS	emotion recognition, emotional behavior, social cognition, mirror mechanism	F. Caruana
IBPM	Hydrogen sulfide, a signaling molecule across life kingdoms	drug targets, signalling, bacterial physiology	A. Giuffré
IBBC	Identification and treatment of early cognitive deficits during ageing to prevent dementia	ageing, dementia, Alzheimer disease, autophagy, sex differences	E. De Leonibus
IBBC	Identification and treatment of neural mechanisms underlying early behavioral symptoms in Parkinson's disease	Memoria motoria, plasticità sinpatica, malattia di Parkinson, retina, alfasinucleina	E. De Leonibus
IGB	Identification of druggable molecular pathways underlying neurodevelopmental disorders	Single-cell RNA sequencing; Neuro-inflammation and microglia; Anti-seizure drugs	M.G. Miano
IBPM	Identification of inhibitors of the unique trypanothione metabolism to fight parasitic neglected diseases	neglected diseases; structural biology; structure based drug discovery	G. Colotti, A. Ilari
IBBC	Identification of miRNA and /or circRNA involved with Parkinson Disease	progranulin, parkinsonism, genetics, dementia, gaze palsy, CRISPR-Cas9, Induce Pluripotent Stem Cells (iPSCs)	E. Vitale
IBFM	Identification of molecular imaging markers in PD mouse models	PD mouse models, Early disease markers, PET-CT imaging	S. Belloli
IBFM	Identification of radio-epigenomic signatures in oncology	Radiomics, Epigenomics biomarkers, Bioinformatics	F. Gallivanone
IN	Identification of recovery-associated prognostic biomarkers and novel cellbased therapeutic strategies	stroke, biomarkers, cell-based therapy	C. Alia
IRGB	Idiopathic pulmonary fibrosis (IPF) and lung cancer	Idiopathic Pulmonary Fibrosis, Lung Cancer, NGS	I. Persico, M.C. Sini, S. Casula
IBFM	Imaging Biomarkers in Parkinsonism	Parkinsonism, Imaging, Biomarkers	A. Quattrone
IBFM	Imaging microvascular dysfunction	Blood Flow, Coronary circulation physiopathology, Magnetic resonance, Positron emission tomography	O. Rimoldi
IBFM	Imaging of neuroinflammation in different neurodegenerative disorders	Neuroinflammation models, Anti-inflammatory therapy, PET-CT imaging	S. Belloli
CIN	Immune challenge within the European Green Deal: profiling the impact of food-borne micro- and nanoplastics on human immune system	immunotoxicology, microplastics, predictive models	P. Italiani, on behalf of the IBBC-CNR Immunology Group NAPOLI
IBPM	Immune regulation and immuno-monitoring in human diseases: auto-immunity, cancer, and COVID-19	immuno-monitoring; immuno-therapy; cellular senescence	F. Di Rosa, F. Antonangeli
IEOS	Immunological Self-tolerance and Metabolism	immunological self-tolerance, metabolism, Treg cells	G. Matarese
IFT	Impact of mutant p53 on miRNA biogenesis in colon cancer	miRNA, colon cancer, mutant p53	A. Gurtner
IGM	Improving the quality of life in progeria: a first trial in the murine Lmna G609G/G609G model using tocilizumab and different drug combinations	---	E. Schena, G. Lattanzi et al.
IBFM	In silico discovery of candidate drugs against COVID-19	Bioinformatics, COVID-19, Drugs	C. Cava
IBFM	In silico drug discovery for cancer therapy	Bioinformatics, Cancer, Gene network	C. Cava
IBB	In vitro diagnostic turbidimetric methods for SARS-CoV-2	Sars-CoV-2; Diagnostic test; Turbidimetry	V. Menchise
IN	In vivo imaging of cortical plasticity in mouse models of stroke	fluorescence imaging in vivo, mouse model of stroke, rehabilitation	A.L.A. Mascaro
IN	Increased response to 3,4 methylenedioxymethamphetamine (MDMA) reward and altered gene expression in zebrafish during short- and long-term nicotine withdrawal	Psychostimulants, Conditioned Place Preference, reward, receptors	M. Sala
IBBC	Induction of Innate Immune Memory by Engineered Nanoparticles	innate memory, nanoparticles, monocytes/macrophages	P. Italiani
IRGB	Induction of therapeutic levels of HbF in genome edited primary β°39-thalassemia HSPCs	β-thalassemia, Fetal hemoglobin induction, CRISPR/Cas9	M. G. Marini
IEOS	Inflammation, immunity and cancer	inflammation, DNA damage, cancer immunotherapy	R.M. Melillo, A, Celetti, N. Prevete
IBBC	Innovative neuroimaging techniques applied to animal models to assess Neuroinflammation in Alzheimer’s Disease	Small animal SPECT, Super Spatial Resolution, Neuroimaging application	R. Massari
IBPM	Innovative therapeutic strategy for Duchenne Muscular Dystrophy by AAV mediated delivery of artificial transcription factor genes	Duchenne Muscular Dystrophy; artificial zinc finger transcription factor; gene therapy	IBPM - IBBC
IGB	Insights in Glioblastoma and Neural Stem Cell biology	glioblastoma, neural stem cells, quality management tools	G.L. Liguori
ITB	Integrated approach based on transcriptomic and proteomic platforms to identify the biological mechanisms underlying the ALS disease	transcriptomics, proteomics, ALS	R. Bordoni, P. Mauri
ITB	Integrated Multidisciplinary Approaches to uncover Molecular Mechanisms underlying Complex and Rare Neurological Diseases and their Phenotypes	Neurological Rare Diseases, Transcriptomics, Biomarkers	M. Liguori, N. Nuzziello
ITB	Integrating pharmacogenomic and pharmacometabolomic data towards personalized opioid therapies for cancer pain	SNP, GWAS, drug response	F. Colombo
ITB	Integration of exosome mirnome/proteome signature for identification of specific glioblastoma biomarkers	extracellular vesicles; microRNAs; glioblastoma	I. D'Agnano
IBBC	Interaction Between Neurogenic Stimuli and the Gene Network Controlling the Activation of Stem Cells of the Adult Neurogenic Niches, in Physiological and Pathological Conditions	neural stem cells activation, in vivo, neurogenic niches, hippocampus, memory, aging, neurodegenerative diseases	F. Tirone, L. Micheli
IBBC	Intestinal T-cell based assays: from basic science to translational application for treatment of celiac disease	mucosal immunology; celiac disease, T cells, bioassays	C. Gianfrani
IRGB	Intracellular trafficking in kidney development and pathophysiology	Endocytosis, Autophagy, Development, hESc, Organoids, Disease modeling	L. Staiano
IN	Investigating a new molecular mechanism acting upstream of the formation of neurotoxic Aβ1-42 species: novel therapeutic strategies for Alzheimer’s disease	RNA binding proteins; drug design; RNA metabolism	A. Borreca
IRGB	Investigating molecular and cellular pathophysiological mechanisms of the bone tissue	bone, osteoclast, osteoblast, genetics, murine models	C. Sobacchi
IRGB	Investigating the role of host-microbiota interaction in the pathogenesis of immunemediated disorders	immunity, immunodeficiency, immune-mediated disease, microbiota, infection	B. Cassani c/o Humanitas Clinical and Research Center
IBB	Investigating tumor pH imaging as a novel cancer biomarker	imaging, therapy, tumor metabolism	D. Longo
IRGB	IPSC-based models for investigating mechanisms primary cardiomyopathies: focus on LMNA gene and its pathophysiological role in the human cardiomyocyte	Induced Pluripotent Stem Cells (iPSCs); Cardiomyopathy; Lamin A/C	E. Di Pasquale c/o Humanitas Clinical and Research Center
IBPM	Leukocyte telomere length as possible biomarker to track Huntington’s disease progression	Huntington’s Disease; biomarker; Leukocyte Telomere Length	D. Scarabino, E. Mantuano
IGM	Leveraging 3D chromatin architecture for the study of non-coding regulatory regions variants	Computational genomics; Epigenetics; 3D chromatin architecture	F. Ferrari
ITB	Linked-read sequencing for the discovery of structural variants in autism spectrum disorders	autism; linked-read sequencing, structural variants	A. Mezzelani
IRGB	Liquid biopsy in clinical oncology	liquid biopsy, circulating tumor DNA (ctDNA), anti-EGFR therapy	M. Casula, M. Pisano
IN	Longitudinal Health and Cross-Country Statistical Modelling	Harmonization, Cross-country comparability; Longitudinal studies	N. Minicuci
IBB	Machine Learning for Clinical Radiobiology	Radiotherapy, toxicity analysis, personalized medicine	G. Palma
IN	Mapping and molecular fingerprinting of synaptic memory engrams	Alzheimer’s disease, associative learning and memory, dendritic spines	M. Mainardi
IFC	Maternal obesity and cognitive dysfunction in the offspring: cause-effect role of the GUT MicrobiOMe and early dietary prevention (GUTMOM)	maternal obesity, microbiome, cognitive function	P. Iozzo
IN	Mathematical modelling	diabetes, cardiovascular diseases, mathematical modelling	R. Bizzotto
IRGB	Mechanisms of cardiac disease and reverse cardiac remodeling during unloading	Heart failure, cardiomyopathy, mouse models, non-coding RNA	M.L. Bang
IGM	Mechanisms that modulate replication fork stability and R-loop accumulation during the conflict with transcription	DNA Damage; Replication-Transcription Collisions; R-loops	G. Liberi
IBFM	Mechanisms underlying the predictive power of high skeletal muscle uptake of FDG in amyotrophic lateral sclerosis	Amyotrophic lateral sclerosis; Endoplasmic reticulum; Oxidative stress; SOD1G93A mouse model; Skeletal muscle; [18F]-Fluorodeoxyglucose.	C. Marini
IBBC	Medulloblastoma, tumor of the cerebellum: novel in vivo models and preclinical therapies	cerebellar precursor cells, cerebellum development, medulloblastoma, gene therapy	F. Tirone, M. Ceccarelli, L. Micheli
IGB	Metabolic control of cell plasticity in physiology and disease	cell plasticity, cell metabolism, drug-screening	C. D'Aniello, E.J. Patriarca
IN	Metabolic interventions to heal FoxG1-related Rett syndrome	intellectual disability, autism spectrum disorders, epilepsy	M. Mainardi
IGM	Metabolic reprogramming and cancer progression	metabolic reprogramming, metabolomics, cancer progression	G. Zadra
IBFM	Metabolomics Facility-ISBE Joint Research Unit	Health, Metabolomics, Systems Biology	D. Gaglio
IBIOM	Metastatic spread and cancer chemoresistance: genetic and epigenetic mechanisms	Epigenetics, cell signaling, metastasis	L. Moro
IBBC	microRNAs and LncRNAs in brain ageing and Alzheimer Disease	miR-101, LncRNAs, Neurons, Hippocampus, Ageing, Alzheimer’s Disease	C. Barbato, F. Ruberti
IBFM	microRNAs as theranostics molecules in cancer	microRNAs, Bioinformatics, Theranostics	C. Cava, G. Bertoli
IN	Microtomography of cerebral microcirculation in murine models of chronic pain	X-ray nanotomography, chronic pain, neurovascular coupling	A. Zippo
IBIOM	Mitochondria: Hubs for signal pathways, cellular energetics and redox balance	Mitochondria; signal transduction; oxidative stress	L. De Rasmo
IBIOM	Mitochondrial carriers: metabolic roles and pathologies	mitochondrial carrier characterization, mitochondrial disease, drug-screening	E. Paradies
IFC	MMM – Medical Mockup Modelling	mockup, 3D, cardiac imaging	C. Torino
IFT	Modulation of adult neurogenesis as a potential therapeutic tool for Alzheimer’s disease	adult neurogenesis; Alzheimer’s disease; Ab-oligomers; intracellular targeting; intrabody; contextual fear conditioning	R. Scardigli
ITB	MOLECULAR AND CELLULAR BIOLOGY FINDINGS	Precision and regenerative medicine; biomarkers (coding, non-coding and chromatin-complexes); high-throughput transcriptomics and super resolution microscopy	F. Adorni, Igea D'Agnano
IN	Molecular and cellular mechanisms underlying the relationship between metabolic alterations and cognitive decline	dietary interventions, cognitive decline, metabolism	M. L. Malosio
IGB	Molecular and functional effects of methylglyoxal on human microvascular retinal cells	diabetic retinopathy; retinal endothelium; transcriptional network	A. Ciccodicola, M. Aprile
IBB	Molecular dynamics simulation approach to study UV-induced DNA damage	Molecular Dynamics simulations, DNA oxidative damage, G-quadruplex	L. Esposito
IGB	Molecular mechanisms governing angiogenesis in health and disease	Angiogenesis, VEGF family, pathological neovascularization related diseases	S. De Falco
IGB	Molecular mechanisms of bone diseases and tumors	bone diseases; skeletal sarcomas; Paget’s disease of bone; ZNF687; PFN1	F. Gianfrancesco
IBBC	Molecular mechanisms of membrane fission at the Golgi complex	Membrane traffic, Membrane Fission, Cellular Imaging	D. Corda, C. Valente, A. Luini
IN	Molecular mechanisms of synaptic dysfunction in UBE3A-linked neurodevelopmental disorders	synaptic development, excitatory/inhibitory balance, CRISPR/Cas9, in utero electroporation, super-resolution microscopy, proteomics	M. Fossati
IRGB	Molecular mechanisms underlying cardiac muscle contraction and novel therapeutic approaches	heart, cardiac disease, ion channel, calcium homeostasis, therapeutic approach, bioactive molecule, drug delivery, nanoparticles	D. Catalucci
IBBC	MOLECULAR STUDY OF GLUT1 DEFICIENCY SYNDROME: FUNCTIONAL CHARACTERIZATION OF CAUSATIVE MUTATIONS AND NEW GENOTYPEPHENOTYPE CORRELATIONS	GLUT1, non-coding RNA	C. Parisi
IN	Monoamine oxidase A dependent ROS formation activates Akt/GSK3β signaling pathway to drive human cardiac differentiation	reactive oxygen species, hiPSCs, cardiomyocytes	N. Kaludercic
IBPM	Moonlighting proteins in mitosis: new roles for splicing and nucleolar proteins	mitosis; moonlighting proteins; splicing factors	C. Pellacani, P. Somma
IN	MOTOR LEARNING	motor and cognitive development, action observation training, sport skills	M. Fabbri Destro
ITB	Multi-omics data and biological networks analysis for precision medicine	Multi-omics, interactome, data integration	E. Mosca
IRGB	MUTATION PROFILES IN MELANOMA INITIATION AND PROGRESSION	MAPK pathway, NGS, melanomagenesis	M. Colombino, A. Manca
IRGB	Mutational status of main oncogenes and microsatellite instability in Sardinian patients with advanced colorectal cancer	Colorectal cancer, RAS-BRAF genes, microsatellite instability	G. Palomba, M. Colombino, G. Maestrale
IN	Myocardial overexpression of ANKRD1 causes sinus venosus defects and progressive diastolic dysfunction	ANKRD1, cardiac development; diastolic dysfunction; hemodynamics	M. Campione
IGB	Myofibroblastic activation in breast tumor microenvironment and inhibition of cancer-associated fibroblasts pro-invasive activity by novel peptides	metastatic dissemination; αv Integrin; breast cancer-associated fibroblasts	M.P. Stoppelli
IBFM	Nanocarriers and targeting agents for imaging and treatment (theranostics)	Nanocarriers, PET/SPET imaging, Theranostics	S. Todde, S. Belloli
IBFM	Nature-Inspired Biomedical Image Analysis for Precision Medicine	Nature-inspired computing, Artificial intelligence, Medical image analysis, Biomedical data integration	C. Militello
IN	Network alterations in vivo in mouse models of autism and epilepsy	autism, epilepsy, changes in network excitability	S. Landi
IN	NEUROAESTHETICS	artworks, architecture, arousal, valence, approach-avoidance, body representations	G. Vecchiato
IN	NEUROBIOLOGY OF LANGUAGE	language production, language comprehension, embodied cognition, motor theory of speech perception	F. Caruana
IBBC	Neurobiology of memory capacity	memory capacity, neuronal circuits, AMPA receptors, dopamine, sex differences, cortical-subcortical plasticity, optogenetics	E. De Leonibus
IBBC	Neuroinflammatory Markers in the Serum of Children with Down Syndrome, DiGeorge Syndrome, and Klinefelter Syndrome	NGF, BDNF, TNF-α, TGF-β, MCP-1, IL-1α, IL-2, IL-6, IL-10, IL-12, oxidative stress, genetic rare diseases	M. Fiore
IN	Neuromodulation and rehabilitation after stroke and brain damage	neuromodulation, rehabilitation, robotics	C. Spalletti
IBFM	Neuroncology, treatment assessment with molecular imaging and biology	Glioblastoma multiforme, Therapy, Molecular imaging and omics sciences	S. Valtorta
IFT	Neuroni chimicamente indotti come modello per lo studio dei meccanismi patogenetici e lo sviluppo di nuove strategie diagnostiche molecolari nelle malattie degenerative	Malattie neurodegenerative, Transdifferenziamento, Conformeri proteici	C. Mollinari
IFT	Neuropharmacology of NGF and proNGF	Nerve Growth Factor, Traumatic Brain Injury, Clinical Trials	L. Manni, M. Soligo
IBBC	Neuroprotective and inflammatory factors in neurodegenerative diseases: potential biomarkers	Alzheimer’s and Parkinson’s diseases, chemokines, biomarkers, blood, cerebrospinal fluid	C. Severini, IBBC Unit at Department of Sense Organs, Sapienza University of Rome
IBFM	Neuropsychiatric features in Dementia & Neurodegeration	Dementia, Neurodegeneration, Functional MRI, Structural MRI, Neuropsychiatry, Neuropsychology, Computational neuroscience, Psychopharmacology, Biomarkers	L. Passamonti
IFT	Neurotropic Viruses and Neurodegenerative diseases	Neurotropic viruses, neurodegenerative disease, antivirals	G. De Chiara
IEOS	New biomarkers and therapeutic targets of human cancer	aptamers, HMGA, lncRNA	L. Cerchia, M. Fedele, S. Zannini
IGM	Non-coding RNA components of the DNA damage response in neurodegeneration and diseases	Genome Stability; non coding RNA; neurodegeneration	F. d’Adda di Fagagna, S. Francia
IN	Novel interdisciplinary approaches to molecular pathogenesis of Congenital Central Hypoventilation Syndrome: from basic to drug discovery	PHOX2B, poly-alanine expansion disorders, IPS	R. Benfante
IFC	Novel precision technological platforms to promote non-invasive early diagnosis, eradication and prevention of cancer relapse: proof of concept in the bladder carcinoma (EDIT)	nanomedicine, bladder cancer, gold nanorods, photoacoustic imaging, hyperthermia	L. Menichetti, F. Faita
IGM	Nucleotide excision repair (NER)-defective disorders as model system for carcinogenesis, neurodegeneration and ageing	NER disorders, transcription regulation, cell cycle control	E. Botta, F.A. Peverali, D. Orioli
IBBC	Nutrition, metabolic disorders, aging, gender-differences, maternal and post-natal environment in incidence of neuropathy and pain: revealing new and selective pharmacological targets for a personalized medicine	autophagy, myelin, glia, disease-related biomarkers, immune cells	S. Marinelli, V. Vacca, S. Luvisetto, F.R. D’Amato, F. Pavone
IGB	OTX2 controls epiblast contribution to germline and soma	Otx2, pluripotency, primordial germ cells	A. Simeone, D. Acampora, L.G. Di Giovannantonio
IFT	p63 network in epithelial tumors	squamous carcinogenesis, p53 family, transcription regulation, cancer cell stemness, Extracellular matrix-mediated signaling, lncRNAs	A. Peschiaroli
IFT	PASSIVE IMMUNIZATION WITH ANTIBODY TARGETING N-TERMINAL TRUNCATED TAU REVERSES NEUROPATHOLOGY AND COGNITIVE DEFICITS IN TWO PRECLINICAL MOUSE MODELS OF AD	Tau cleavage, immunotherapy, Alzheimer’s Disease (AD)	G. Amadoro
IBBC	Pathogenetic mechanisms and therapeutic approaches for myotonic dystrophy	myotonic dystrophy, circular RNAs, pathogenetic mechanisms, gene therapy	G. Falcone
IRGB	Pathophysiology and cure of immune bone inherited defects	Immunodeficiency, Osteopetrosis, Gene Therapy	M.C. Castiello, V. Capo, A. Villa
IFT	Pathophysiology of reactive astroglia and microglia	Glia, Microglia, Neurodegenerative diseases	L. Marlier
IRGB	Pbx1-directed stem cell transcriptional program drives tumor progression in myeloproliferative neoplasm	Myeloproliferative neoplasm, JAK2V617F, Hematopoietic stem cells, Pbx1	F. Ficara c/o Humanitas Clinical and Research Center
IBBC	Perspectives For Future Innovation in Tendon repair (P4 FIT)-H2020-MSCA-ITN-EJD- 955685	tendon regenerative medicine; nanomedicines; stem cells; bioactive molecules, immunomodulation; artificial intelligence; biosensors; bioimaging, preclinical studies	B. Barboni
IBBC	Pharmacological targeting CtBP1/BARS-controlled endocytic pathway to block SARS-CoV2 infection	COVID-19, Membrane trafficking, Cellular Imaging	C. Valente
IFT	Phospho-TCTP and Dihydroartemisinin: a Novel Therapeutic Opportunity in Advance Breast Cancer	prognostic factor, combination therapy	M. Lucibello
IRGB	Pilot study of neonatal genetic screening in the Ogliastra population (Neogenia)	screening, variants, genotyping	F. Cucca
IRGB	Post GWAS analysis of a BCL11A intronic region to define its role in regulating HbF levels	Thalassemia; Fetal Hemoglobin; GWAS	M. Uda, C. Caria, F. Crobu
IRGB	Precision medicine in colorectal cancer: new clinical-genomic network for expanding tailored oncologic care	Colorectal Cancer (CRC), Transcriptome, Single Cells (SC)	A. Angius
IGB	Precision medicine in Parkinson's disease: an integrated multidisciplinary approach to develop innovative protocols for early diagnosis and disease progression	Diagnostic/prediction protocols for Parkinson’s Disease (PD); humanized mouse models for PD; Circulating biomarkers	T. Esposito
IN	Prenatal inflammation and altered neurodevelopment: the role of MeCP2	synapse dysfunction, synaptogenesis, cytokines, maternal inflammation, neurodevelopment	I. Corradini
IGB	Prioritization of causative genomic variants in miscarried embryos from idiopathic pregnancy losses	miscarriages, variant prioritization, whole-genome DNA sequence	V. Colonna, S. Buonaiuto
IBBC	Promising therapeutic applications of botulinum neurotoxins: nerve regeneration and functional recovery in a spinal cord injury mouse model	botulinum, spinal cord, regeneration, neuroprotection, anti-inflammatory action	S. Luvisetto, V. Vacca, F. Pavone, S. Marinelli
IFC	Promoting patient safety by a novel combination of imaging technologies for biodegradable magnesium implants (MgSafe)	Diagnostic tools (e.g. genetic, molecular diagnostic), Materials engineering, In vitro cell and tissue imaging, In vivo bio- and medical- imaging, Medical engineering and Technology	L. Menichetti, D. Panetta
IBBC	Protective effect of a multi-strain probiotic (BP-002) in a mouse model of neuroinflammation induced by LPS: role of gut-brain axis	Gut Brain Axis, Neuroinfammation, Adult neurogenesis, LPS, Probiotics	S. Farioli-Vecchioli, C. Petrella, F. De Santa, G. Strimpakos
IBBC	Protein mono-ADP-ribosylation in the control of cell physio-pathology	mono-ADP-ribosylation; membrane transport; cancer	G. Grimaldi
IBFM	Proteomics and metabolomics studies of adrenal cancer and benign adrenal neoplasia: new in-sights in the pathogenesis of adrenal masses	Proteomics, Metabolomics, Adrenal cancer	M. Ripamonti
IFT	Protocolli di immunizzazione genetica mediante elettroporazione e identificazione di biomarcatori in patologie tumorali	gene electrotransfer; pre-clinical protocols; biomarkers	E. Signori
IBBC	Pyrvinium Pamoate drug Induces Death of Triple-Negative Breast Cancer Stem– Like Cells and Reduces Metastases through its effects on Lipid Anabolism	breast cancer, cancer progression, metastasis, stem cell biology, molecular markers of metastasis and progression, cancer metabolism, lipid anabolism, mitochondria, OxPHOS, computational methods, gene expression profiling, molecular modeling	L. Cardone
IN	Quantification of vascular microangioarchitectures in physiopathological neural contexts	anti-angiogenesis, vascular retina, AMD	M. Righi
IGB	Quantitative analysis of immunological memory	Immunological memory, antibody, β-amyloid	A. Prisco
IBFM	Radiomics for Preclinical and Clinical Applications	Radiomics, Biomedical image analysis,Preclinical and clinical studies, Machine learning, Deep learning	A. Stefano
IBFM	Radiotherapy and biologic effects of radiations	Radiotherapy; Adrotherapy, Radiobiology; Radiosensitization; Space radiobiology	IBFM-CNR, Cefalù team
IN	Reciprocal interactions between astrocytes and neurons in brain physiology and pathology	Astrocytes, calcium, GCaMP6f, optogenetics, chemogenetics, synaptic transmission, synaptic plasticity, memory, Dravet syndrome, Alzheimer’s disease, BDNF, entorhinal/perirhinal/somatosensory/visual cortex, hippocampus, ventral tegmental area	G. Carmignoto
IBBC	Regulation of Golgi unlinking during G2/M transition	Golgi complex, cell cycle, PKD, MAPK kinase	I. Ayala
IBBC	REGULATION OF THE BIOSYNTHETIC MEMBRANE TRANSPORT APPARATUS	Membrane transport, control systems, autoregulation	A. Luini
IFT	Regulation of the stress response in inflammation, cancer and viral infection	HSF, anticancer drugs, inflammation, proteotoxic stress, NF-kappaB, viral infection	A. Rossi, M.G. Santoro
IFT	Regulatory Science and translational drug development	Regulatory Science, Technology Transfer, drug discovery	P. Pierimarchi
IFT	Research Team: Monica Rinaldi, Sandra Iurescia, Daniela Fioretti	---	M. Rinaldi, S. Iurescia, D. Fioretti
IFT	Resolution of inflammation: pro-resolving lipid mediators as novel diagnostic and therapeutic strategies	Chronic inflammation, resolution, lipids, innate and adaptive immunity, biomarkers, resolution pharmacology	V. Chiurchiù
IBPM	Response to glucocorticoids in cultured hippocampal neurons from mdx mice and in human and mouse cell lines	glucocorticoids; Duchenne Muscular Dystrophy; stress	P. Fragapane
IBBC	Re-Using old drugs against cancer: Computational drug repurposing identified decitabine for targeted therapy in KRAS-dependent Pancreatic Ductal Adenocarcinoma by exploiting pyrimidine biosynthesis addiction	pancreatic cancer, functional genomics, cell death and senescence, drug targets, oncoprotein, small molecule agents, oncogenes, cancer metabolism, pyrimidine biosynthesis, drug discovery technologies, in silico evaluation of drug repurposing	L. Cardone
IEOS	Risk for Type 2 Diabetes and comorbidities – a molecular perspective	Cancer; Diabetes; Epigenetics	V. D'Esposito
IN	Role of biological markers for the risk stratification of cerebral bleeding and ischemic stroke in patients with atrial fibrillation on oral anticoagulants for primary or secondary prevention of ischemic stroke: the Strat-AF2 Study	Atrial fibrillation, circulating biomarkers, ischemic stroke	A. Di Carlo
IN	Role of Calcium activity in cell invasion and migration by Intravital Two-photon Imaging of Glioblastoma Mouse Models	changes in network excitability, GBM models, peritumoral/tumoral area	S. Landi
IBBC	Role of cell cycle regulators in the control of skeletal muscle function in physiological and pathological conditions	Muscle metabolism, Cell cycle regulators, muscular dystrophy	M. Caruso
IN	Role of interhemispheric connections in health and disease	corpus callosum, neuronal plasticity, epilepsy	L. Restani
IN	Role of microglia in the control of synaptic homeostasis	synapse, dendritic spines, synaptic pruning, microglia, innate immune system, TREM2	M. Matteoli
IFT	Role of miR-200c in oxidative stress-induced pathologies	microRNA, oxidative stress, endothelial dysfunction, oxidative stress-associated diseases	A. Magenta
IBPM	Role of noncoding RNAs in neuronal homeostasis and disease	noncoding RNAs; stress; Autism Spectrum Disorder	C. Mannironi
IN	Role of Pentraxin3-thrombospondin1 complex in neurodevelopmental diseases	synapse dysfunction, synaptogenesis, synaptic plasticity, AMPA receptors, glial cells, innate immune system	E. Menna
IN	ROLE OF RARE MISSENSE VARIANTS OF THE HUMAN β4 (BETA) SUBUNIT IN THE EXPRESSION AND SURFACE EXPOSURE OF α3β4 NICOTINIC RECEPTORS	Neuronal nicotinic receptors; intracellular trafficking; missense variants	S. F. Colombo
IN	Role of Tau in chromatin remodeling and gene expression	Tau, Chromatin, gene expression	C. Di Primio
IFT	Scientific dissemination – "Comunicare La Ricerca"	Scientific dissemination	S. Iurescia, D. Fioretti
IGM	Screening platform for anticancer and antiviral drugs	antiviral/anticancer drug development, small molecule inhibitors, target validiation	G. Maga, E. Crespan
IBBC	SENSORY DECAYS and AGING (SENSAGING)	Sensory system, aging, genomics, metabolomics, functional analysis, sensory decay	M. Raspa, A. Tettey Matey
ITB	Single Cell transcriptomic analysis of tumor patient-derived organoids	Single Cells Analysis, Breast Cancer, Organoids	P. Pelucchi, E. Mosca
IBFM	Sleep and Neurodegeneration: novel biomarkers for new challenges	Sleep Disorders, Alzheimer’s Disease; Parkinson’s Disease	M. Salsone
IN	SOCIAL AND MOTOR ASPECTS OF AUTISM SPECTRUM DISORDERS	autism spectrum disorders, motor development, social cognition, mirror mechanism	M. Fabbri Destro
IN	Social implications and neural correlates in planning and execution of licking behavior	motor planning, licking, social facilitation	C. Alia
IRGB	Soluble BAFF Inhibition by small molecules: Virtual Screening drug discovery driven by genetics	Virtual Screening, genetics, assay	S. Olla, F. Cucca
IFT	SOSTANZE NATURALI: IMMUNOFARMACOLOGIA ED ONCOLOGIA INTEGRATA	resveratrolo, polidatina, dual target drug, neoantigeni, caspasi inibitori, IL-1β, infiammazione	M.P. Fuggetta
IBB	Spectroscopic analysis and biological evaluation of novel synthetic molecules and natural drugs for biomedical applications	G-quadruplex, anticancer strategies, spectroscopic methods	G.N. Roviello
IBBC	sPLA2-IIA regulates osteoclast differentiation and function	Phospholipase A2, osteoclastogenesis, p-38 SAPK	S. Mariggiò
IBPM	Spontaneous RNA polymerization and ricombination: implications for RNA metabolism and the "RNA World" hypothesis	origin of life; prebiotic chemistry; RNA world	G. Costanzo, A. Cirigliano,
IBBC	SSR-SPECT/CT device: a new method for the small animal imaging study	Small animal SPECT, Monte Carlo simulation, Super Spatial Resolution, Neuroimaging	R. Massari
IRGB	Statistical methods for powerful identification of causal mechanisms underlying complex traits and diseases	Causal inference, Microbiome, cholesterol	S. Sanna
IBPM	Stereocontrolled total synthesis of iminosugars and their lipophilic derivatives with potential therapeutic activity	stereodivergent synthesis; iminosugars; drug delivery.	G. Righi, A. Ricelli
IBIOM	Strategy for p53 tumour suppressor reactivation in chemo-resistant tumours	p53, TRIM8, chemoresistance	A. Tullo
IBB	Structural characterization of the porphyrins/proteasome interaction	Porphyrins, Proteasome inhibitors, NMR spectroscopy	D. Diana
IBB	Structure-based approaches for therapeutic and diagnostic applications	protein structure; antibiotic; cancer	R. Berisio
IRGB	STUDIO FUNZIONALE DI VARIANTI DEL LOCUS CD40 ASSOCIATI ALLA PREDISPOSIZIONE A MALATTIE AUTOIMMUNI	Sclerosi Multipla, CD40, CD27	A. Meloni, V. Faà, I. Asunis, F. Cucca
IBBC	STUDY OF NEW PHARMACOLOGICAL TARGETS FOR AUTISM SPECTRUM DISORDER BY USING INNOVATIVE NEUROIMAGING TECHNIQUES APPLIED TO THE CONSCIOUS LABORATORY ANIMAL	Autism spectrum, social behaviour, Small Animal SPECT, lightweight scintigraphyc devices	R. Massari
IBPM	Studying the role of long noncoding RNAs in neuronal physiology and their impact in brain cancer and neurodegeneration	noncoding RNAs; brain tumours; neurodegeneration	E. Caffarelli, P. Laneve
IN	Synaptic dysfunctions and potential therapies for Phelan McDermid Syndrome	Shank3, SULT4A1, synapse	C. Verpelli
IFT	TACKLING INTRATUMOR HETEROGENEITY: SEARCHING FOR NEW CURE	ITH (IntraTumor Heterogeneity); Genomics; Metabolism	V.M. Fazio
IBBC	Targeted vaccination using novel nano-carriers	filamentous bacteriophage, vaccine, dendritic cells, invariant natural killer T cells, alphagalactosylceramide, anti tumor immunity.	P. De Berardinis, R. Sartorius, L. D’Apice
IN	Targeting Ca2+ and mitochondrial dysfunctions to fight neurological deficits	excitotoxicity, calcium and mitochondrial dynamics, cell death	B. D'Orsi
IBPM	Targeting DNA damage and autophagy as potential therapeutic approach for cancer and neurodegenerative diseases	3D model system; cancer; Ataxia Telangiectasia	V. Stagni
IFT	Targeting epithelial and hematologic cancer by Fcγ-CR engineered T cells or longterm NK cells	Fcγ-CR T cells, NK cells, cancer immunotherapy	G. Sconocchia, S. Caratelli, G. Lanzilli
IN	Targeting inflammation to rescue cone photoreceptors inRetinitis Pigmentosa (RP)	retina, inflammation, blindness	E. Strettoi
IBBC	Targeting metabolic disturbances of central cholinergic circuits to recover cognition in AD and T2D	NGF, BFCN, brain insulin resistance, oxysterols, Alzheimer’s Disease, T2D	V. Triaca
IBIOM	TARGETING MITOCHONDRIA IN NEURODEVELOPMENTAL DISEASES	Mitochondrial dysfunction; neurodevelopmental diseases; bioactive natural compounds	R. A. Vacca
IRGB	Targeting mitochondria to treat rare and common neurodegenerative disorders	Mitochondria, MicroRNA, Neurodegenerative Disorders	A. Indrieri
IGB	Targeting oncogenic lncRNA and tumor cell metabolism to overcome drug resistance in BRAF-mutated thyroid carcinomas	Molecular Oncology; Drug Resistance; Omic Technologies	V. Costa
IBB	Targeting Sam-Sam interactions mediated by EphA2 receptor: design and evaluation of peptide inhibitors	ONCOLOGY; STRUCTURAL BIOLOGY; NMR	M. Leone
IGB	Targeting the cancer (stem) cells – tumor microenvironment crosstalk to improve pancreatic cancer prognosis	Pancreatic Cancer Stem Cells; TGFbeta; Tumor microenvironment	E. Lonardo
IN	Targeting the oxytocin system: novel therapeutic agents for neurodevelopmental diseases and neuropsychiatric disorders	oxytocin analogues, neuropsychiatric disease, neurodevelopmental disorders	M. Busnelli, B. Chini
IBPM	Telomeres structure and function: from the safeguard of genetic stability to cell immortality	telomeres; G-quadruplexes; cancer	E. Salvati
IBFM	Temporal Lobe Epilepsy (TLE): Circulating microRNAs as biomarkers for the differential diagnosis and prediction of therapeutic response in TLE	TLE circulating biomarkers, Diagnosis, Drug-resistance prediction	C. Cava, I. Manna, A. Gambardella, G. Bertoli
IBB	The crystal structure of KCTD1 prompts for a new structural/functional re-classification of the KCTD protein family	domain swapping, protein function, human disease	L. Vitagliano
IFT	The effects of NGF, proNGF forms and their receptor inhibition on immune response in chronic inflammatory diseases	Inflammation, cytokines, NGF receptors	L. Bracci Laudiero
IBFM	The elusive ink between FDG uptake and glucose consumption unravels an unexpected metabolic role of endoplasmic reticulum	Endoplasmic reticulum; PET, cancer; Glucose metabolism neurodegenerative disorders, Oxidative stress; SOD1G93A mouse model; Skeletal muscle; [18F]- Fluorodeoxyglucose	C. Marini
IBBC	The glycerophosphoinositols: definition of the cellular receptor and its involvement in tumor invasion	Glycerophosphoinositols, Src homology region 2 domain-containing phosphatase-1 (Shp1), actin cytoskeleton	A. Varone
IBPM	The HIPK2 kinase/spastin axis in cancer and neurodegeneration	pancreatic cancer; organoids; Hereditary Spastic Paraplegia	C. Rinaldo
IRGB	The impact of ageing, sex, environment and genetics in the immune system: an integrated approach to dissect immunosenescence	immune system, ageing, genetics	M. Steri, V. Orrù, E. Fiorillo, F. Cucca
IFT	The impact of the ubiquitin-system in tumorigenesis	Ubiquitin-dependent degradation, protein stability, E3 ubiquitin ligases, WWP1	A. Peschiaroli
ESFRI-INFRAFRONTIER	The Infrafrontier Landmark Research Infrastructure and the European Mouse Mutant Archive (EMMA) - Mouse Disease Models for the Scientific Community	bio-repository, phenogenomics, preclinical research, translational and personalised medicine	emma@infrafrontier.eu, mouse.resources@emma.cnr.it
IN	The interaction of the mitochondrial inhibitor protein IF1 with ATP synthase modulates the permeability transition pore in a human cancer cell model	IF1, Permeability Transition Pore, cancer, ATP synthase	V. Giorgio, V. Petronilli
ESFRI-INFRAFRONTIER	The International Centre for Genetic Engineering and Biotechnology (ICGEB) - European Mouse Mutant Archive (EMMA). Workshops and courses on mouse models of disease and genome editing.	mouse models, genome editing, embryo manipulation, human diseases	S. Zacchigna (ICGEB), M. Raspa (IBBC-EMMA), A. Muro (ICGEB), E. Lippolis (ICGEB)
IRGB	The interplay between cellular aging and immune response in human colorectal liver metastasis: senescence as a new prognostic marker?	Cellular Senescence, Metastasis, Immune cells	F. Faggioli
IBBC	The intriguing life of SMN at the plasma membrane: not only a matter of Spinal Muscular Atrophy	SMN, SMA, RNA metabolism, plasma membrane, ribosome	M.G. Di Certo
IN	THE MIRROR MECHANISM	action execution, action observation, social cognition, mirror mechanism	P. Avanzini
IGM	The RNA helicase DDX3X in cancer and viral infections	RNA helicase DDX3X, broad spectrum antivirals, alternative ribonucleotide excision repair	G. Maga
ITB	The Role of TMEM230 in angiogenesis, tissue remodeling and autoimmunity	angiogenesis, tissue remodeling, autoimmunity, 3D cellular models	C. Cocola
IFT	The study of metabolic alterations in Amyotrophic Lateral Sclerosis: a new therapeutic approach	Amyotrophic Lateral Sclerosis, Hypermetabolism, Bioenergetics	A. Ferri, C. Valle
IFT	The Wnt/β-catenin pathway as therapeutic target for oncological and neurodegenerative diseases	Wnt/β-catenin pathway, Parkinson’s disease, cancer therapy and diagnosis	A. Serafino
IBB	Theranostic nanoparticles based approach targeting a set of microRNAs in drug resistant breast cancers	Preclinical Molecular Imaging, Breast Cancer, Theranostic nanoparticles	A. Zannetti
IFT	Therapeutic strategies to target glioblastoma multiforme: the cancer stem cells model	Glioblastoma cancer stem cells, anti-cancer drugs, immunotherapy	C. Cenciarelli
IGB	Toward the reactivation of the dormant allele of MECP2 as a therapy for Rett syndrome: a dual-reporter system to trace the allele specific expression of Mecp2 and study its function in neurogenesis	Mecp2-pathies, X chromosome reactivation, epigenetics	M. Vacca, L. Casalino
IBBC	Translational medicine in HEAD/NECK CANCER: Laryngeal carcinoma	Cancer; invasiveness; growth factors; neuropeptides; vgf; stem cells; human tumor bioptic tissues	IBBC Unit at Department of Sense Organs, Sapienza University of Rome
IN	Translational Neuroscience and Brain Training	brain plasticity, dementia, environmental enrichment	A. Sale
IGM	Translesion synthesis and DNA damage tolerance	Damage tolerance, polymerase eta, DNA Replication	S. Sabbioneda
IGM	TSPYL2, a sex specific player in the DNA damage response of cancer cells	DNA damage, apoptosis, sexual dimorphism	L. Zannini
IBBC	TTF-2/FoxE1 as co-repressor of thyroid hormone receptors activity	thyroid, estrogen, FoxE1/TTF-2, thyroid-specific gene expression	D. Civitareale
IN	Tumor growth of neurofibromin-deficient cells is driven by decreased respiration and hampered by NAD+ and SIRT3	Neurofibromin, SIRT3, TRAP1	I. Masgras
IN	Understanding changes that occur in peritumoral tissue during glioma progression and finding novel approaches to develop effective therapeutic strategies to counteract glioma growth	glioma; brain tumor; epilepsy	E. Vannini
IEOS	Unraveling the role of dicarbonyl stress in the progression of type 2 diabetes and vascular dysfunction	Diabetes Mellitus; Endothelial dysfunction; Glucotoxicity	C. Miele, C. Nigro
IBBC	Unravelling the signaling and molecular pathways downstream Golgi fragmentation	Golgi complex, cell cycle checkpoint, signaling, Antibody Microarray	D. Spano
IBIOM	YEAST AS A MODEL FOR FUNDAMENTAL AND APPLIED CELL BIOLOGY	mitochondria, signaling, humanized yeast	S. Giannattasio
IBBC	ZIMMERMANN-LABAND SYNDROME: FUNCTIONAL STUDIES TO CHARACTERIZE CAUSATIVE MUTATIONS IN KCNH1 GENE	Neurodevelopmental disorders, primary cilium, KCNH1	C. Parisi