Contributions@DSB | List Abstracts

Mechanistic Insights into Neurological Disorders and New Therapeutic Strategies - July 2021

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103 records found
Inst.	Title	Keywords	Contacts
IN	3D CLEARED BRAIN IMAGING IN MOUSE AND ZEBRAFISH TO QUANTITATIVELY DETECT CELL ACTIVATION	brain clearing; quantitative analysis; antigen-binding saturation; immunofluorescence; signal-to-noise ratio	S. Morara
IBPM	A DROSOPHILA ANIMAL MODEL FOR INVESTIGATING THE NEUROLOGICAL DEFECTS ASSOCIATED WITH CONGENITAL DISORDERS OF GLYCOSYLATION	Congenital disorder of glycosylation, Golgi, Drosophila melanogaster	M.G. Giansanti
IN	A new AAV cassette for enhancing the efficacy and safety of a gene therapy approach for the treatment of Rett syndrome	Rett syndrome, gene therapy, AAV, neurodevelopmental disorder	M. Luoni
IN	A new mechanism for the spreading of amyloid pathology in Alzheimer’s disease	Microglia, extracellular vesicles, beta amyloid, Alzheimer’s disease, synaptic dysfunction	C. Falcicchia, N. Origlia
IGB	A new mouse model to study dynamics of Mecp2 allelic expression under random X chromosome inactivation during development: implications in neurogenesis and Rett Syndrome pathogenesis	Rett Syndrome, Mecp2, allelic expression, epigenetics, in vivo imaging	L. Casalino, M. Vacca
IN	Abnormal behaviors and neuronal functions in mice lacking Shank3 in parvalbumin-expressing interneurons	Phelan McDermid Syndrome, GABA, Ganaxolone	J. Pagano, C. Verpelli
IGM	ALS-linked cytoplasmic inclusions alter DNA-Damage Response activation	ALS, TDP-43, FUS, DNA damage, DNA repair	S. Francia, F. d'Adda di Fagagna
IN	Alterations of Ca2+ signalling in astrocytes in mouse models of Alzheimer’s disease	Alzheimer’s disease, PS2APP model, astrocytes, Ca2+ signalling	M. Zonta
IRIB	Altered insulin pathway induces mitochondrial dysfunction and impairs autophagy in in vitro and in vivo model systems	insulin pathway, neurodegeneration, mitochondrion, mitophagy, aging	M. Di Carlo
IBBC	Altered metabolism of heparan sulfate leads to developmental dopaminergic abnormalities responsible for autistic-like behaviours in lysosomal storage disorders	lysosomal storage disorders, autism, dopamine, neurodegeneration, heparan sulfate	E. De Leonibus
IRIB	Bioengineering approaches to investigate CLN8-VAPA interaction in CLN8-diseases	CLN8, Neuronal Ceroid Lipofuscinoses, EPMR, VAPA, sphingolipids, autophagosome-lysosome	P. Guarneri
IN	Brain circuits of fear attenuation	Remote fear memory extinction, nucleus reuniens (NRe), chemogenetics, optogenetics, fiber photometry	B.A. Silva
IN	BRIDGING THE GAP BETWEEN THE OXYTOCIN AND DOPAMINE RECEPTORS: A NEW STRATEGY TO TREAT NEUROPSYCHIATRIC DISORDERS	oxytocin, dopamine, schizophrenia, novel therapeutics	M. Busnelli
IBPM	Celf2a inhibition: a new strategy to ameliorate Duchenne Muscular Dystrophy symptoms	DMD, lncRNAs, iPSCs, exon skipping	J. Martone
IBPM	CENP-F, A MITOTIC KINETOCHORE PROTEIN IMPLICATED IN MICROCEPHALY	Neurodevelopment, Microcephaly, CENP-F, mitosis, primary neurons	P. Lavia
IBFM	Circulating microRNA: The Potential Novel Diagnostic Biomarkers to Predict Drug Resistance in Temporal Lobe Epilepsy, a Pilot Study	microRNA, diagnosis, prognosis, temporal lobe epilepsy	G. Bertoli, I. Manna
IRIB	CLINICAL, GENETIC AND EPIGENETIC CORRELATES IN CHILD ABUSE	Child Abuse Syndrome (CAS); neuropsychiatric disorders; genomic screening; target therapy	X.G. Pappalardo, E. Parano
IBBC	Crossing the blood-brain barrier of AD mouse models: Nanogels for targeted drug delivery	Alzheimer’s disease, Mouse models, Blood-brain barrier, Nanogels, anti-inflammatory drugs	M. Gori
IBPM	Deciphering the neuroprotective role of Sigma1 Receptor, an important function to overcome the symptoms of neurodegenerative disorders	Huntington Disease, Virtual screening, Sigma-1 Receptor, Drug repositioning strategy	G. Colotti, A. Ilari, V. Morea
IBFM	Decoding the causal links between Sleep Apnea and Alzheimer’s Disease	Alzheimer’s Disease (AD), Obstructive Sleep Apnea (OSA), Magnetic Resonance Imaging (MRI), hippocampous, amygdala	M. Salsone
IGB	Derangement of glycosphingolipid metabolism in brain of MeCP2-/y Rett syndrome mouse model	Rett syndrome, MeCP2, glycosphingolipids, AUTS2, epigenetics	F. Della Ragione
IBFM	Development and Validation of a New Wearable Mobile Device for the Automated Detection of Resting Tremor in Parkinson’s Disease and Essential Tremor	---	R. Nisticò
IN	Developmental impaired Akt signaling in the Shank1 and Shank3 double knock-out mice	Autism, intellectual disability, synapse, cotinine	J. Pagano, C. Verpelli
IBPM	Disease modeling of tubulinopathies using Drosophila melanogaster	TUBB2A, neurodegenerative disorders, neurodevelopmental disorders, transgenic flies, iPSC	M. Di Salvio
IN	Dissecting olfactory circuits’alterations in mouse models of Parkinson’s disease	Parkinson’s disease, mouse models, Olfactory bulb Neuronal oscillations, Multi-photon imaging	C. Lodovichi
IGM	DNA damage and DNA damage response in Alzheimer’s disease	---	F. d'Adda di Fagagna, S. Sepe
IBPM	DROSOPHILA MELANOGASTER MODELS IN NEUROLOGIC AND NEURODEGENERATIVE DISEASES	leukodystrophy, ataxia, sensorineural deafness, RNF220	G. Cestra, F. Cipressa
IEOS	Elucidating the extracellular vesicle-associated determinants modulating Foxp3 expression and suppressive function of T regulatory cells in multiple sclerosis	Multiple Sclerosis; T regulatory cells; Foxp3; extracellular vesicles; microRNA	A.L. Ferrara
IN	Endoplasmic Reticulum Stress as a possible connection between metabolic alterations and cognitive decline	insulin resistance, hippocampus, anxiety, cognitive impairment, metabolic disorders	S. Penati, M.L. Malosio
IBPM	Epigenetic reprogramming of Fibro-Adipogenic Progenitors promotes repair and prevents degeneration of dystrophic muscles	Fibro-adipogenic progenitors, H3K9 methylation, epigenetic reprogramming, nuclear lamina, muscular dystrophy	C. Mozzetta
IN	ER-SHAPING PROTEINS AND THEIR ROLE IN NEURONAL CALCIUM HOMEOSTASIS	Hereditary Spastic Paraplegia; Endoplasmic Reticulum; Store-Operated Calcium Entry; Drosophila melanogaster; Calcium imaging	D. Pendin
IBBC	Estrogenic hormones counteract Facioscapulohumeral Muscular Dystrophy (FSHD) features in a mouse model of muscle regeneration	FSHD, estrogens, muscle regeneration, perivascular cell, gender medicine	S. Maiullari, F. Moretti
IBFM	Exploring the neuroprotective effects of Montelukast treatment in a rat model of quinolinic acid-induced neurotoxicity	Huntington’s disease, PET, neuroinflammation, glucose metabolism, connectivity	S. Belloli
IN	Extracellular Vesicles analysis in cerebrospinal fluid of transgenic pigs: a model for biomarker discovery in Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis, superoxide dismutase, extracellular vesicles, pig model, ALS biomarkers	S.F. Colombo
IBBC	Fostering neuron-glia energy metabolism by nasal NGF: a common strategy in neurodegenerative diseases	NGF therapy, neuron-glia, brain insulin resistance, 27-OH, neurodegeneration	V. Triaca
IRIB	Fragile X Syndrome: neurobiology and therapeutic perspectives	Fragile X, mGlu5 receptors, 5-HT7 receptors, astrocytes, stress granules	M.V. Catania
IBPM	From molecular mechanisms to therapeutic strategies: how to increase the level of spastin in Hereditary Spastic Paraplegia (HSP)?	Hereditary spastic paraplegia (HSP); spastin; phosphorylation-dependent stability; polyubiquitylation/degradation; NEDDylation inhibitors	C. Rinaldo
IN	Functional characterization of SULT4A1 a gene deleted in Phelan McDermid Syndrome	NMDAR, PIN1, excitatory synapse	L. Culotta, C. Verpelli
IN	GABA TONIC CONDUCTANCE IS ALTERED EARLY DURING DEVELOPMENT IN A MOUSE MODEL OF DRAVET SYNDROME	Dravet syndrome; GABA; seizures; Nav1.1; SCN1A	G. Losi
IBBC	GBM Group: a new interdisciplinary team of IBBC investigating the gut-brain axis	gut-brain axis, probiotics, neuro-inflammation, adult neurogenesis, mice models	S. Farioli Vecchioli
IBBC	GENE THERAPY STRATEGIES FOR MYOTONIC DYSTROPHY TYPE 1	myotonic dystrophy type 1, CRISPR/Cas9, gene therapy	G. Falcone
IBBC	HOME CAGE DETECTION OF SLEEP DISTURBANCES IN A MOUSE MODEL OF ALS	ALS, SOD1G93A mice, sleep, home cage monitoring, mouse behavioral phenotyping	S. Mandillo
IGB	Identification of druggable molecular pathways damaged in X-linked neurodevelopmental disorders	developmental and epileptic encephalopathy; cortical malformations; animal disease models; omic-platforms; drug discovery	M.G. Miano
IGB	Identification of sixteen novel candidate genes for late onset Parkinson’s disease: polygenic variants load and Parkinson’s disease risk	Late onset Parkinson’s disease, Whole Exome Sequencing, Novel candidate genes for Parkinson’s disease, Rare variant burden analysis	T. Esposito
IN	Impact of OPHN1 mutation on inhibitory interneurons	Intellectual disability-Autism, inhibitory interneurons, migration, imaging, OPHN1	C. Lodovichi
IN	Impact of UBE3A dosage on synapse development: between the Angelman Syndrome and Autism	synapse development; ubiquitination; excitation/inhibition ratio; STED microscopy	M. Fossati
IBBC	Inhibition of selected microRNAs in neuronal cells and development of Alzheimer’s Disease models	Neurons, microRNAs, miR-101, Microglia	F. Ruberti
IBPM	Innovative therapeutic strategy for Duchenne Muscular Dystrophy by AAV mediated delivery of artificial transcription factor genes	AAV, DMD, utrophin, zinc finger artificial transcription factor, NMJ	C. Passananti
IBPM	Insights into the ASD-related circular RNA circRmst	Autism Spectrum Disorder, circRNA, Rmst, ncRNA, brain development	C. Mannironi
IBBC	Interaction Between Neurogenic Stimuli and the Gene Network Controlling the Activation of Stem Cells of the Adult Neurogenic Niches, in Physiological and Pathological Conditions	Adult neurogenesis, aging brain, RNA-seq expression analysis, neural stem cells reactivation, mouse models	L. Micheli, F. Tirone
IRIB	Interruptions of the FXN GAA repeat tract delay the age at onset of Friedreich’s ataxia in a location dependent manner	Ataxia, GAA repeat, interruptions	F. Cavalcanti
IFT	Intracellular interference with Aβ oligomers rescues adult hippocampal neurogenesis and memory deficit of Tg2576	adult hippocampal neurogenesis, Alzheimer’s disease, neural stem cells, intracellular Aβ oligomers, intrabody	R. Scardigli
IBPM	Lamotrigine rescues neuronal alterations and prevents seizure-induced memory decline in an Alzheimer’s disease mouse model	Alzheimer’s Disease; hippocampus; epilepsy; neuronal excitability; lamotrigine	C. Marchetti
IBBC	Large-scale analysis highlights the role of epigenetics in Facioscapulohumeral muscular dystrophy (FSHD)	FSHD, DUX4, Epigenetic, DNA Methylation, D4Z4	G. Deidda
IN	Lateral habenula dysfunctions in Tm4sf2 -/y mice model for neurodevelopmental disorder	Lateral habenula, TSPAN7, Intellectual disability, Autism spectrum disorder, Neurodevelopmental disorders	L. Murru
IBPM	Leukocyte telomere length analysis in patients with spinocerebellar ataxias (SCA1, SCA2, SCA3)	spinocerebellar ataxias (SCA1, SCA2, SCA3), Leukocyte Telomere Length (LTL), Neurodegenerative Disease, Trinucleotide repeat expansion Disease	D. Scarabino
IN	Long-lasting synaptic potentiation of excitatory transmission to dopamine neurons by astrocytes in the Ventral Tegmental Area	Astrocyte, dopamine neurons, Ventral Tegmental Area, Ca2+ signalling, synaptic plasticity	M. Gomez-Gonzalo
IN	mGlu5 receptor signaling alteration in Phelan McDermid syndrome	mGlu5 PAM, protein translation, autism, intellectual disability	F. Giona, C. Verpelli
IN	Microglia-specific overexpression of alpha-Synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity	Parkinson’s disease, Microglia, Neuroinfiammation, Neurodegeneration	V. Broccoli
IN	Middle cerebral artery photothrombosis as a promising model to resemble human ischemic stroke	photothrombotic stroke, behavioral deficit, hemorrhage, immunofluorescence	M. Baldereschi
IRGB	Modulation of miR-181a/b ameliorates mitochondrial-mediated neurodegeneration	MicroRNAs, mitochondria, Mitochondrial Diseases, Parkinson’s disease, gene therapy	A. Indrieri
IBPM	Molecular characterization of pyridoxine 5'-phosphate oxidase and its pathogenic forms associated with neonatal epileptic encephalopathy	pyridoxal 5’-phosphate, pyridoxine 5’-phosphate oxidase, enzyme kinetics, PNPO deficiency, allosteric regulation	A. Tramonti
IBB	MRI-CEST approach for investigating tumor metabolism	imaging, tumor, acidosis, metabolism, MRI	D. Longo
IRIB	Natural Biomolecules and Brain-Derived Nanovesicles for Neurodegenerative Diseases	biomolecules; nanovesicles; nanotechnology; neurodegenerative processes	D. Nuzzo, P. Picone
IFT	Nerve growth factor in paediatric severe traumatic brain injury	Nerve growth factor; traumatic brain injury; clinical trial; animal model	L. Manni, M. Soligo
IBIOM	Networking-based prediction of involvement of differentially expressed lncRNAs in Alzheimer’s Disease	lncRNAs, Alzheimer’s Disease, transcriptome, bioinformatics	E. Filomena, A.M. D'Erchia
IBB	Neuroinflammatory and neurodegenerative sequelae from iron/fibrin deposits in a mouse model of altered cerebral venous drainage	cerebral venous drainage, fibrin deposits, iron deposits, neuroinflammation, neurodegeneration	S. Albanese, M. Mancini
IFC	Neurophysiological modifications after probiotics administration in preschoolers with autism	Autism Spectrum Disorders, probiotics, connectivity, GABAergic, cytokine	L. Billeci
IFT	Neuroprotective effect of Pomalidomide in a Drosophila model of Parkinson's disease	Parkinson, Drosophila, LRRK2, neuroprotection, drug repurposing	M. A. Casu
IBFM	New brain atlas tool for Parkinson’s disease images analysis	Brain atlas tool, PET imaging, SPM analysis, neuroinflammation, Parkinson’s disease	S. Belloli
IN	New insights into methoxetamine mechanisms of action: focus on serotonergic 5HT-2receptors in pharmacological and behavioral effects in the rat	Methoxetamine; Serotonin; 5-HT2 receptors; sensorimotor responses; GABA; glutamate	L. Fattore
IBBC	Novel strategy to enhance adult neurogenesis through the CrispR/cas9 –mediated conditional knockdown of p21 Waf1/Cip1 gene	p21, adult neurogenesis, dentate gyrus, behaviour, traumatic brain injury	S. Farioli Vecchioli
IN	Nuclear Tau modulates gene expression leading to glutamate release alterations during AD progression	Nuclear Tau, Alzheimer’s disease, glutamate release, excitotoxicity, gene expression	C. Di Primio, G. Siano
IN	Nucleolin suppresses ALS-related TDP-43 toxicity in yeast and mammalian cell models	amyotrophic lateral sclerosis, TDP-43, proteinopathies, nucleolin, misfolded proteins	M.L. Massimino, F. Tonello
IFT	PATHOGENIC FUS PROMOTES THE EXPRESSION OF AGGREGATION-PRONE SPLICING ISOFORMS OF HNRNPA2B1 IN AMYOTROPHIC LATERAL SCLEROSIS	Amyotrophic Lateral Sclerosis, motor neuron degeneration, RNA alternative splicing, FUS, hnRNP A2/B1	M. Cozzolino
IGB	Pharmacological rescue of the brain cortex anomalies of Tbx1 mouse mutants	Vit. B12; 22q11.2 deletion syndrome; Tbx1; mouse model; pharmacological rescue	G. Lania
IBPM	Post-transcriptional regulation of the pan-neurotrophin receptor p75NTR during neuronal differentiation	Neurotrophins, p75NTR, axon specification, non-coding RNAs, neuronal differentiation	C. Giorgi
IFT	PSYCHOMETRIC SCALES IN CLINCAL PSYCHOPHARMACOLOGY TRIALS	Psychometry, Combinatorial, Statistic, Informativity	G. Marchese
IFT	Recurrent HSV-1 infection induces AD hallmarks and cognitive deficits in mice	herpes simplex virus-1; Alzheimer’s disease; mouse model; neurodegenerative processes; antivirals	G. De Chiara
IFC	REDUCED CCL11/EOTAXIN MEDIATES THE BENEFICIAL EFFECTS OF SENSORIMOTOR STIMULATION ON THE AGED HIPPOCAMPUS	aging, inflammation, eotaxin, learning and memory, neural plasticity, neurogenesis	M. Maffei, M. Mainardi, G. Scabia
IN	Removal of chronic pain symptoms by in vivo microsections of rat somatosensory cortex with parallel high-energy X-ray microbeams	chronic pain, X-ray, cortical columns, lateral connectivity, analgesia	A.G. Zippo
IN	Rescuing epileptic phenotype and behavioral alterations in a Dravet syndrome mouse model by inhibiting eukaryotic elongation factor 2 kinase (eEF2K)	GABAergic synapse, neurodevelopment, intellectual disability, autism	S. Beretta
IN	Restoration of Scn1a expression after symptom onset in a novel model of Dravet syndrome rescues seizures and behavioral alterations	Dravet syndrome, epilepsy, neurodevelopmental disorder, autism	S. Brusco
IN	Role of Pentraxin3 in neurodevelopmental diseases	synapse dysfunction, synaptogenesis, PTX3, AMPA receptors, glial cells, inflammation	E. Menna, G. Fossati
IN	SCNA gene triplication and isogenic iPSC-derived neuronal cultures for modeling alpha-Synuclein aggregation and neurotoxicity	Parkinson’s disease, cell reprogramming, Synuclein, Lewy bodies, neurodegeneration	A. Iannielli
IN	SETBP1 accumulation induces P53 inhibition and genotoxic stress in patient stem cell-derived neural progenitors underlying neurodegeneration in Schinzel-Giedion syndrome	Schinzel-Giedion syndrome, neurodegeneration, neurodevelopmental disorder, epigenetics, chromatin	F. Banfi
IN	SIGMA-1RECEPTOR MUTATION CAUSES DYSREGULATION OF CELL HOMEOSTASIS AND INTRACELLULAR CA2+ SIGNALING IN dHMN PATIENT CELLS	Sigma-1Receptor, hereditary neuropathies, Ca2+ signalling, ER-mitochondria contacts, neurodegeneration	G. Pallafacchina
IBBC	Structural evidences for the role of CD33 SNP rs2455069 in Alzheimer disease progression	CD33, Single-Nucleotide-Polymorphism (SNP), Alzheimer's disease, Neurodegeneration, Sialic acid-binding immunoglobulin-type lectin (Siglec)	E. Vitale
IBBC	Synaptic Correlates of Anterograde Amnesia and Intact Retrograde Memory in a Mouse Model of Alzheimer's Disease	AMPA/NMDA, Alzheimer’s disease, anterior cingulate cortex, hippocampus, memory	S. Middei
IN	Targeting mitochondrial calcium to fight neurological deficits: the role of the mitochondrial calcium uniporter (MCU)	MCU, calcium, excitotoxicity, cell death, Alzheimer’s disease	B. D'Orsi
IFT	Targeting the Wnt/β-catenin pathway by Natriuretic Peptides: an attractive therapeutic approach for Parkinson’s disease	Wnt/β-catenin pathway; Neurodegeneration; Natriuretic Peptides; Neuroprotection and Neurorepair; Parkinson’s disease	A. Serafino
IGM	TENDON ALTERATIONS IN MUSCULAR DYSTROPHIES: IMPLICATIONS FOR THE ONSET OF JOINT CONTRACTURES	Emery-Dreyfuss muscular dystrophy, collagen VI related myopathies, tendon, TGFβ2, extracellular-matrix	S. Squarzoni, G. Lattanzi
IBB	The crystal structure of KCTD1 redefines the evolutionary connections among KCTD proteins	Domain swapping, Structure-function relationships, X-ray crystallography, Neurodevelopmental disorders	L. Vitagliano
IN	The Effect of Adherence to the Mediterranean Diet on Late-Life Cognitive Disorders: A Systematic Review	Mediterranean diet, cognitive decline, MCI, Alzheimer’s disease, dementia	F. Limongi
IBBC	The GPRC5B and GPR37L1 G protein-coupled receptors modulate Megalencephalic Leukoencephalopathy proteins	Megalencephalic Leukoencephalopathy with subcortical Cysts, GPCRs, proteome, adhesion molecules	C. Di Pietro, D. Marazziti
IGM	THE MECHANOSIGNALING NETWORK OF DIFFERENTIATING MYOBLASTS UNDER MECHANICAL STRAIN	muscle differentiation, mechanical strain, muscular dystrophies, ECM, nuclear envelope	E. Mattioli, G. Lattanzi
IN	THE NOVEL POSITIVE ALLOSTERIC MODULATOR OF THE GABAB RECEPTOR, KK-92A, SUPPRESSED ALCOHOL SELF-ADMINISTRATION AND REINSTATEMENT OF ALCOHOL SEEKING IN RATS	GABAB receptor; Positive allosteric modulators; KK-92A; Alcohol-related behaviors; Animal models of alcohol use disorder	P. Maccioni, G. Colombo
IN	The Oxytocin system in the developing brain: evidence from mouse models of neurodevelopmental disorders	Oxytocin, social brain, neurodevelopmental disorders, GPCR signalling, drug design	B. Chini
IBIOM	Therapeutic use of polyphenols in children with Down syndrome: from the "in vitro" to the clinic	Down syndrome, mitochondrial dysfunction, neurogenesis impairment, polyphenols, nutraceuticals	R.A. Vacca, D. Valenti
IBB	Thyroid Hormone Enhances Angiogenesis and the Warburg Effect in Squamous Cell Carcinomas	Thyroid Hormones, Deiodinases, Cancer, Angiogenesis, Squamous Cell Carcinoma	M. Dentice, M. Mancini
IBBC	To fine-tune autophagy as therapeutic challenge in prevention of neuropathy and pain	Schwann cells autophagy, Wallerian Degeneration, Neuropathic Pain, Caloric restriction, autophagy inducer	S. Marinelli
IN	Understanding the neuronal and synaptic dysfunctions caused by deletions and mutations of TCF20 intellectual disability gene	transcription factor, synapse formation, dendrites, iPSCs-derived neurons	E. Vinci, C. Verpelli
IN	Wolframin, mutated in Wolfram disease, is an ER-resident protein involved in ER stress and autophagy	Wolfram syndrome, neurodegeneration, autophagy, ER stress	G. Rossi