Pubblicato su Nature Cell Biology l'articolo: "SARS-CoV-2 causes DNA damage, cellular senescence and inflammation", autore Fabrizio D'Adda di Fagagna, AIRC Institute of Molecular Oncology (IFOM ETS), Milan, Italy - Institute of Molecular Genetics (IGM) of National Research Council (CNR) - Pavia, Italy.

"We discovered that SARS-CoV-2 infection causes DNA damage both in cultured cells and in vivo. Mechanistically, SARS-CoV-2 degrades the enzyme CHK1, which leads to a reduction in dNTPs and impaired DNA replication. Moreover, inhibition of the formation of binding protein 53BP1 foci by the SARS-CoV-2 nucleocapsid protein hinders the repair of damaged DNA. The ensuing accumulation of DNA damage causes cellular senescence and inflammation."